| Weill Cornell Medicine |
$150,000 |
New York, NY, US |
To Identify Regulators Of Lineage Reversion That Impact Resistance To Wnt-targeted Therapies In Colorectal Cancer. |
2021 |
| Fox Chase Cancer Center |
$75,000 |
Philadelphia, PA, US |
To Investigate The Role Of Brg1-depedent Epigenetic Regulation On Pdac Fibroblast Pro-tumorigenic Functions. |
2021 |
| Brigham And Women's Hospital Inc |
$150,000 |
Boston, MA, US |
To Uncover And Validate Druggable Targets That Can Be Combined With Mek/erk Inhibitors To Treat Ras Pathway-driven Malignancies, Especially Melanoma. |
2021 |
| Dana-farber Cancer Institute |
$75,000 |
Boston, MA, US |
To Optimize Usp8 Inhibitors And Test Their Activity In Models Of Neurodegenerative Disease, Non-small Cell Lung Cancer, And Other Applicable Systems. |
2021 |
| Massachusetts Institute Of Technology |
$150,000 |
Cambridge, MA, US |
To Investigate The Role Of Diet And Nutrient Availability In Tumor Growth, Progression, And Response To Treatment. |
2021 |
| Memorial,Sloan-kettering,Cancer,Center |
$75,000 |
New York, NY, US |
To Investigate The Molecular Mechanisms Underlying How Endgogenous Dna-modifying Enzymes Lead To Cancer Genome Evolution. |
2021 |
| Nyu,School,Of,Medicine |
$75,000 |
New York, NY, US |
To Investigate How Metabolic Rewiring In Distinct Genetic Subtypes Of Lung Cancer Impacts Immune Cell Infiltration And Leads To Immune Evasion. |
2021 |
| Massachusetts,Institute,Of,Technology |
$150,000 |
Cambridge, MA, US |
To Engance Nanoparticle Accumulation In Desired Cell Types To Develop More Effective And Safer Targeted Nanotherapies. |
2021 |
| Whitehead,Institute,For,Biomedical,Research |
$100,000 |
Cambridge, MA, US |
To Investigate The Role Of Trna-derived Fragments And The Genes They Regulate In Breast Cancer Progression And Metastasis. |
2021 |
| Salk,Institute,For,Biological,Studies |
$100,000 |
La Jolla, CA, US |
To Investigate The Potential Of Ca19-9 As A Therapeutic Target For Pancreatic Cancer Treatment And To Discover Pharmacological Approaches To Blocking Ca19-9 Production In Malignant Cells. |
2021 |
| University,Of,California,San,Francisco |
$75,000 |
San Francisco, CA, US |
To Develop A Small Molecule That Stabilizes Mutant P53 In Cancer And Further Elaborate This Compound With The Ability To Increase Dna Binding Of Bound P53. |
2021 |
| Johns,Hopkins,University |
$75,000 |
Baltimore, MD, US |
To Investigate How The Colon Microbiota And Host Genetics Intersect To Alter Responsiveness To Immunotherapy In Colorectal Cancer. |
2021 |
| University,Of,Guelph |
$100,000 |
Guelph, Ontario, CA |
To Identify Combinations Of Commercial Bacterial Isolates That Suppress Klebsiella Pneumoniae In The Colon And The Underlying Cooperative Mechanisms Of This Activity. |
2021 |
| Rockefeller,Universtity |
$75,000 |
New York, NY, US |
To Investigate The Role Of Trna-derived Fragments And The Genes They Regulate In Breast Cancer Progression And Metastasis. |
2021 |
| Brigham,And,Women's,Hospital,Inc |
$150,000 |
Boston, MA, US |
To Uncover And Validate Druggable Targets That Can Be Combined With Mek/erk Inhibitors To Treat Ras Pathway-driven Malignancies, Especially Melanoma. |
2020 |
| Dana-farber,Cancer,Institute |
$75,000 |
Boston, MA, US |
To Optimize Usp8 Inhibitors And Test Their Activity In Models Of Neurodegenerative Disease, Non-small Cell Lung Cancer, And Other Applicable Systems. |
2020 |
| Massachusetts,Institute,Of,Technology |
$150,000 |
Cambridge, MA, US |
To Investigate The Role Of Diet And Nutrient Availability In Tumor Growth, Progression, And Response To Treatment. |
2020 |
| Memorial,Sloan-kettering,Cancer,Center |
$75,000 |
New York, NY, US |
To Investigate The Molecular Mechanisms Underlying How Endgogenous Dna-modifying Enzymes Lead To Cancer Genome Evolution. |
2020 |
| Nyu,School,Of,Medicine |
$75,000 |
New York, NY, US |
To Investigate How Metabolic Rewiring In Distinct Genetic Subtypes Of Lung Cancer Impacts Immune Cell Infiltration And Leads To Immune Evasion. |
2020 |
| Regents,Of,The,University,Of,California |
$150,000 |
La Jolla, CA, US |
To (1) Define A Microbiome Growth Curce In Healthy Children, (2) Determine When And Why Deviation From This Curve Occurs, And (3) Investigate Known, As Well As Discover New, Microbiome-linked Disorders And Relationships Among Them, And Analyze Microbiome Associations With Clinical Presentations Of Covid-19. |
2020 |
| Rockefeller,University |
$150,000 |
New York, NY, US |
To Investigate The Role Of Trna-derived Fragments And The Genes They Regulate In Breast Cancer Progression And Metastasis. |
2020 |
| Salk,Institute,For,Biological,Studies |
$75,000 |
La Jolla, CA, US |
To Investigate The Potential Of Ca19-9 As A Therapeutic Target For Pancreatic Cancer Treatment And To Discover Pharmacological Approaches To Blocking Ca19-9 Production In Malignant Cells. |
2020 |
| University,Of,California,San,Francisco |
$150,000 |
San Francisco, CA, US |
To Develop A Small Molecule That Stabilizes Mutant P53 In Cancer And Further Elaborate This Compound With The Ability To Increase Dna Binding Of Bound P53. |
2020 |
| University,Of,Chicago |
$75,000 |
Chicago, IL, US |
To Identify Combinations Of Commensal Bacterial Isolates That Suppress Klebsiella Pneumoniae In The Colon And The Underlying Cooperative Mechanisms Of This Activity. |
2020 |
| Georgetown,University |
$150,000 |
Washington, DC, US |
To Investigate How Usp-13, A Protein Involved In The Clearance Of Misfolded And Abnormal Proteins, May Function As A Regulator To Clear Proteins Implicated In The Development And Progression Of Neurodegenerative Diseases. |
2018 |
| Hackensack,University,Medical,Center |
$75,000 |
Hackensack, NJ, US |
To Evaluate Potential Therapies To Decrease Cell Adhesion Interaction-mediated Drug Resistance In Multiple Myeloma, A Type Of Hematological Cancer Characterized By The Uncontrollable Proliferation Of Plasma Immune Cells In The Bone Marrow. |
2018 |
| Regents,Of,The,University,Of,California |
$150,000 |
La Jolla, CA, US |
To (1) Define A Microbiome Growth Curce In Healthy Children, (2) Determine When And Why Deviation From This Curve Occurs, And (3) Investigate Known, As Well As Discover New, Microbiome-linked Disorders And Relationships Among Them. |
2018 |
| Loyola,University,Of,Chicago |
$150,000 |
Maywood, IL, US |
To Investigate How The Transfer Of Alpha-synuclein Between Cells In The Nervous System Induces Neuroinflammation That Drives Parkinson's Disease Pathogenesis. |
2018 |
| Regents,Of,The,University,Of,Michigan |
$75,000 |
Ann Arbor, MI, US |
To Study The Role Of A Protein Modification Process Known As Ampylation On Heat Shock Protein Function In The Onset, Development, And Progression Of Neurodegenerative Diseases (alzheimer's, Parkinson's, And Huntington Diseases) |
2018 |
| Regents,Of,The,University,Of,Michigan |
$150,000 |
Ann Arbor, MI, US |
To Develop A Novel Cancer Vaccine Using Artificial Virus-like Particles, And To Analyze Its Efficacy In The Development Of Anti-tumor Clearance, And Long-term Immunity. |
2018 |
| Rockefeller,University |
$150,000 |
New York, NY, US |
To Determine The Role Of Brca2 And Other Dna Repair Proteins, Which Are Important For Neural Progenitor Cells Of The Cerebellem, In The Development Of Medulloblastoma, The Most Common Pediatric Brain Malignancy. |
2018 |
| Salk,Institute,For,Biological,Studies |
$150,000 |
La Jolla, CA, US |
To Analyze The Potential Therapeutic Effect Of Blocking Fatty Acid Synthesis In Non-small Cell Lung Cancer Through The Use Of Novel Enzymatic Inhibitors. |
2018 |
| Tisch,Multiple,Sclerosis,Research,Center,Of,New,York,Inc |
$150,000 |
New York, NY, US |
To Elucidate The Cause Of Ms By Investigating 3 Synergistic Factors: 1) The Initial Trigger That Generates The Anitbody Response In Ms; 2) The Role Of Epstein - Barr Virus In The Development Of Autoimmunity In Ms; And 3) The Role Of Anti-myelin Antibodies In Sustaining The Ongoing Demyelination And Disease. |
2018 |
| Uc,San,Diego,Foundation |
$75,000 |
La Jolla, CA, US |
To Examine How The Downregulation Of Ednrb, A Gene Found To Be Selective' In The High Altitude Human Population, Can Preserve Cardiovascular Function During Acute Hyposia. |
2018 |
| Uc,San,Diego,Foundation |
$75,000 |
La Jolla, CA, US |
To Analyze Sequencing Data From Subjects Living In High Altitude Conditions In Kyrgystan With Or Without High Altitude Pulmonary Hypertension, In Order To Select And Screen Candidate Genes For The Development Of Pulmonary Hypertension. |
2018 |
| Hackensack,University,Medical,Center |
$75,000 |
Hackensack, NJ, US |
To Evaluate Potential Therapies To Decrease Cell Adhesion Interaction-mediated Drug Resistance In Multiple Myeloma, A Type Of Hematological Cancer Characterized By The Uncontrollable Proliferation Of Plasma Immune Cells In The Bone Marrow. |
2017 |
| Hospital,For,Special,Surgery |
$100,000 |
New York, NY, US |
To Examine How The Molecule Interferon Contributes To Altered Immune System Activation In Lupus Patients. |
2017 |
| Memorial,Sloan-kettering,Cancer,Center |
$150,000 |
New York, NY, US |
To Induce Activation Of Antigen Presenting Cells, Particularly, Dendritic Cells, In Order To Yield A Robust Anti-tumor T Cell Response At The Tumor Site And Increase Sensitivity To Immune Checkpoint Blockade. |
2017 |
| Rockefeller,University |
$150,000 |
New York, NY, US |
To Determine The Role Of Brca2 And Other Dna Repair Proteins, Which Are Important For Neural Progenitor Cells Of The Cerebellem, In The Development Of Medulloblastoma, The Most Common Pediatric Brain Malignancy. |
2017 |
| Salk,Institute,For,Biological,Studies |
$150,000 |
La Jolla, CA, US |
To Analyze The Potential Therapeutic Effect Of Blocking Fatty Acid Synthesis In Non-small Cell Lung Cancer Through The Use Of Novel Enzymatic Inhibitors. |
2017 |
| Tisch,Multiple,Sclerosis,Research,Center,Of,New,York,Inc |
$150,000 |
New York, NY, US |
To Elucidate The Cause Of Ms By Investigating 3 Synergistic Factors: 1) The Initial Trigger That Generates The Anitbody Response In Ms; 2) The Role Of Epstein - Barr Virus In The Development Of Autoimmunity In Ms; And 3) The Role Of Anot-myelin Antibodies In Sustaining The Ongoing Demyelination And Disease. |
2017 |
| Uc,San,Diego,Foundation |
$75,000 |
La Jolla, CA, US |
To Examine How The Downregulation Of Ednrb, A Gene Found To Be Selective' In The High Altitude Human Population, Can Preserve Cardiovascular Function During Acute Hyposia. |
2017 |
| Uc,San,Diego,Foundation |
$75,000 |
La Jolla, CA, US |
To Analyze Sequencing Data From Subjects Living In High Altitude Conditions In Kyrgystan With Or Without High Altitude Pulmonary Hypertension, In Order To Select And Screen Candidate Genes For The Development Of Pulmonary Hypertension. |
2017 |
| Uc,San,Diego,Foundation |
$100,000 |
La Jolla, CA, US |
To Investigate The Effects Of Intermittent Low Levels Of Blood Oxygen And High Levels Of Carbon Dioxide In The Development Of Atherosclerosis And Cardiovascular Disease. |
2017 |
| University,Of,Minnesota,Foundation |
$100,000 |
Minneapolis, MN, US |
To Investigate The Changes In Methylation Associated With Major Depressive Disorders. |
2017 |
| The,Children's,Hospital,Corporation |
$75,000 |
Boston, MA, US |
To Study The Role Of Protein Modification Process Known As Ampylation On Heat Shock Protein Funciton In The Onset, Development. And Progression Of Neurodegenerative Diseases (alzheimer's, Parkinson's, And Huntington's Diseases). |
2017 |
| Regents,Of,The,University,Of,Michigan |
$150,000 |
Ann Arbor, MI, US |
To Develop A Novel Cancer Vaccine Using Artificial Virus-like Particles, And To Analyze Its Efficacy In The Development Of Anti-tumor Clearance, And Long-term Immunity. |
2017 |
| Georgetown,University |
$150,000 |
Washington, DC, US |
To Investigate How Usp-13, A Proteisn Involved In The Clearance Of Misfolded And Abnormal Proteins, May Funciton As A Regulator To Clear Proteins Implicated In The Development And Progression Of Neurodegenerative Diseases. |
2017 |
| Loyola,University,Of,Chicago |
$150,000 |
Maywood, IL, US |
To Investigate How The Transfer Of Alpha-synuclein Between Cells In The Nervous System Induces Neuroinflammation That Drives Parkinson's Disease Pathogenesis. |
2017 |
| Hackensack,University,Medical,Center |
$75,000 |
Hackensack, NJ, US |
To Evaluate Potential Therapies To Decrease Cell Adhesion Interaction-mediated Drug Resistance In Multiple Myeloma, A Type Of Hematological Cancer Characterized By The Uncontrollable Proliferation Of Plasma Immune Cells In The Bone Marrow. |
2016 |
| Hospital,For,Special,Surgery |
$150,000 |
New York, NY, US |
To Examine How The Molecule Interferon Contributes To Altered Immune System Activation In Lupus Patients And To The High Prevalence Of Lupus In Females. |
2016 |
| Memorial,Sloan-kettering,Cancer,Center |
$150,000 |
New York, NY, US |
To Test The Efficacy Of "armored" Car T Cell Therapy, Which Uses A Patients Own T Cells To Fight Cancer, In Order To Enhance The Anti-tumor Immune Responses Of Patients With Relapsed Chronic Lymphocytic Leukemia (cll). |
2016 |
| Memorial,Sloan-kettering,Cancer,Center |
$150,000 |
New York, NY, US |
To Induce Activation Of Antigen Presenting Cells, Particularly, Dendritic Cells, In Order To Yield A Robust Anti-tumor T Cell Response At The Tumor Site And Increase Sensitivity To Immune Checkpoint Blockade. |
2016 |
| Rockefeller,University |
$150,000 |
New York, NY, US |
To Determine The Role Of Brca2 And Other Dna Repair Proteins, Which Are Important For Neural Progenitor Cells Of The Cerebellem, In The Development Of Medulloblastoma, The Most Common Pediatric Brain Malignancy. |
2016 |
| Salk,Institute,For,Biological,Studies |
$150,000 |
La Jolla, CA, US |
To Investigate The Role Of Telomeres In Organizing Chromosomes Within The Cell And How This Ultimately Affects Aging And The Onset Of Age-associated Diseases. |
2016 |
| Whitehead,Institute,For,Biomedical,Research |
$150,000 |
Cambridge, MA, US |
To Investigate The Role Of Alzheimer's Disease (ad) Risk Geners In The Interplay Between Neurons And Microglia, The Resident Immune Cells Of The Brain, In Order To Gain Novel Insights Into Both Disease Mechanisms And Potential Therapeutic Strategies For Ad. |
2016 |
| Tisch,Multiple,Sclerosis,Research,Center,Of,New,York,Inc |
$150,000 |
New York, NY, US |
To Elucidate The Cause Of Ms By Investigating 3 Synergistic Factors: 1) The Initial Trigger That Generates The Anitbody Response In Ms; 2) The Role Of Epstein - Barr Virus In The Development Of Autoimmunity In Ms; And 3) The Role Of Anot-myelin Antibodies In Sustaining The Ongoing Demyelination And Disease. |
2016 |
| Uc,San,Diego,Foundation |
$75,000 |
La Jolla, CA, US |
To Examine How The Downregulation Of Ednrb, A Gene Found To Be Selective' In The High Altitude Human Population, Can Preserve Cardiovascular Function During Acute Hyposia. |
2016 |
| University,Of,Minnesota,Foundation |
$150,000 |
Minneapolis, MN, US |
To Understand How Dna Methylation Is Affected By Early Chronic Stress, And The Role That This Epigenetic Mechanism Has In The Emergence Of Psychopathology As Well As In Resilience To Adversity. |
2016 |
| Whitehead,Institute,For,Biomedical,Research |
$75,000 |
Cambridge, MA, US |
To Study The Role Of Protein Modification Process Known As Ampylation On Heat Shock Protein Funciton In The Onset, Development. And Progression Of Neurodegenerative Diseases (alzheimer's, Parkinson's, And Huntington's Diseases). |
2016 |
| Uc,San,Diego,Foundation |
$75,000 |
La Jolla, CA, US |
To Analyze Sequencing Data From Subjects Living In High Altitude Conditions In Kyrgystan With Or Without High Altitude Pulmonary Hypertension, In Order To Select And Screen Candidate Genes For The Development Of Pulmonary Hypertension. |
2016 |
| Uc,San,Diego,Foundation |
$150,000 |
La Jolla, CA, US |
To Investigate The Effects Of Intermittent Low Levels Of Blood Oxygen And High Levels Of Carbon Dioxide, A Characteristic Of Obstructive Sleep Apnea Patients, On The Development Of Atherosclerosis And Cardiovascular Disease. |
2016 |